If you're asking about hooking up another 12v voltage source (charger, spare battery, etc.) in parallel to the car's battery so you can remove its positive cable without losing your car's memories (e.g., radio, ECU, OBD-II check light, etc.)...
Then Yes, you can use a light wire, 14 or even 16 ga. The background current for these demands, while the car is off, is only in the range of tens of milliamps (e.g., 0.050 amps), and such light wire offers negligible resistance (i.e., voltage drop) at that tiny current.
I know that you know to be sure to shut off the ignition switch, but also be absolutely sure that no compartment lights are on (e.g., the dome light, because you left a door open; or you're leaving an under-hood or trunk light on (if you have them) because the hood or hatch is up or open! Even a single bulb may draw too much current for the lightest wire.
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