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I switched at 143k, and replaced all front seals within 30k because of seepage. Still comes out the back one a bit.
My car had Drydene changes since new, and I used Castrol after that; it never lost any oil between changes, was right on the top line every time.
I have found that the Rotella 5-40 synth (WalMart, cheaper too) lasts better in my than Mobil 1 or Amsoil, ie I don't have to add a quart between changes (4-5k), which I used to have to do. My car now has about 230k on it.
One advantage to synth is that the flame trap doesn't get clogged. I still check it, but it doesn't need to be cleaned anymore.
I tried extending the change interval with synthetic after I had been using it for a few changes, but didn't like the way the engine sounded, so went back to regular intervals.
I think all oil wears out in 4-5k, so the real advantages are cleaner internals, better cold starting, possible longer engine life, longer seal life (if they have life left), and the flame trap.
One area that really made a difference was putting Synth ATF in the power steering; silk is a good way to describe the feeling.
And Redline MTL if you have a manual trans is worth every exhorbitant penny.
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