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Just to throw the full gamut of 'high speed miss' causes out there - how about a flat cam lobe? At low RPM and power settings the cylinder can breath adequately through the smaller valve opening, but floor it at higher RPMs and suddenly that cylinder can't get a full breath, and will run weaker than the others.
Of course, that's not a problem that would come into play only after 20 miles.
Here's a link with some D-Jet diagnostics. Check the sensors with a multimeter - the coolant temp sensor in particular has a large effect on mixture. The air temp sensor has very little effect.
http://www.icbm.org/erkson/ttt/engine/fuel_injection/d-jet.html
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