According to your description removing any wire except number one makes no change in the running. Do you really mean what you say. That would mean 2, 3, and 4 are not firing?????? If wires are in bad shape you should replace them all, along with plugs, dist cap, rotor. Check for sticking valve by running a compression check. Have you considered an injector not working? While trying to isolate a problem to a particular cylinder it is helpfull to disable the idle air control system which otherwise will try to keep idle the same and make it more difficult to observe changes.